A practical Bayesian adaptive design incorporating data from historical controls
نویسندگان
چکیده
منابع مشابه
The Paired Availability Design for Historical Controls
BACKGROUND Although a randomized trial represents the most rigorous method of evaluating a medical intervention, some interventions would be extremely difficult to evaluate using this study design. One alternative, an observational cohort study, can give biased results if it is not possible to adjust for all relevant risk factors. METHODS A recently developed and less well-known alternative i...
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While randomization is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favors one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favored treatment, rather than enr...
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While randomisation is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favours one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favoured treatment, rather than e...
متن کاملIncorporating historical control data into the design and analysis of clinical trials
A standard two-arm randomised controlled trial usually compares a novel treatment to a standard of care. Patients are randomised 1:1 to each treatment and the analysis is based only on patients within the current trial. While historical data is often used informally to design trials, in choosing endpoints and forming the basis of sample size calculations, only recently has it been considered fo...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2018
ISSN: 0277-6715
DOI: 10.1002/sim.7897